hemeonclinx Medical News about Thiopurine-Induced Hematopoietic Toxicity

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Krishnamurthy P et al. - Mrp4 protects against thiopurine-induced hematopoietic toxicity by actively exporting thiopurine nucleotides. The authors then identified a single-nucleotide polymorphism (SNP) in human MRP4 (rs3765534) that dramatically reduces MRP4 function by impairing its cell membrane localization. This SNP is common (>18%) in the Japanese population and indicates that the increased sensitivity of some Japanese patients to thiopurines may reflect the greater frequency of this MRP4 SNP.

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