Richie JP et al. – Mild iron deficiency and low glutathione (GSH) levels, which are associated with increased oxidative stress, increase the risk of oral cavity cancer Methods
Study of the risk of oral cavity cancer in relation to serologic levels of iron; vitamins A, B2, C, E; zinc; thiamin; and GSH
Review of 65 hospitalized pts with oral cancer and 85 matched controls
Results
In comparison of highest to lowest tertiles, risk was: odds ratio (OR) 0.3 for iron; 3.2 for total iron binding capacity (TIBC); 0.4 for transferrin saturation (iron/TIBC times 100)
Associations stronger in never smokers vs ever smokers
Risk associated with the iron storage protein ferritin was significantly elevated, which may reflect disease-related inflammation or comorbidity
OR 0.4 for GSH; OR 1.6 for GSH reductase activity coefficient (indicative of riboflavin deficiency)
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