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Quantification of PSA mRNA levels in peripheral blood of patients with localized prostate adenocarcinoma before, during, and after radical prostatectomy by quantitative real-time PCR (qRT-PCR)
International Urology and Nephrology, 07/03/08

Kalfazade N et al. - In a study to evaluate the clinical value of detected prostate-specific antigen (PSA) mRNA expression levels in circulating cells in pts with prostate cancer by qRT-PCR and determine the effect of surgical manipulation on hematogenous dissemination, it seems that highly detectable PSA mRNA expression levels in preoperative samples seem to be a significant predictable factor for prostate cancer recurrence

Methods

Blood samples before, during, and after (24 h) surgery were obtained from 34 pts with prostate cancer who underwent radical prostatectomy for detecting PSA mRNA expression levels
PSA mRNA expression levels, PSA levels, and Gleason scores were then compared

Results

PSA mRNA expression levels were detected in 14 of 34 pts, and biochemical recurrence of blood PSA was observed in 6 of 34 pts
Differences of PSA mRNA expression levels in pre-, per-, and postoperative periods were statistically significant and differences of PSA mRNA expression levels in pre- and peroperative samples, pre- and postoperative samples, and per- and postoperative samples were also statistically meaningful
There was significant relationship between the detectable PSA mRNA expression levels in preoperative samples and biochemical recurrence of blood PSA levels
Surgical manipulation had no effect on biochemical recurrence of blood PSA
There was significant correlation between high Gleason score and the detectable PSA mRNA expression levels