Wolpin BM et al. - Higher prediagnostic levels of plasma folate were not associated with an increased risk of colorectal cancer–specific or overall mortality. Methods
Study to investigate the influence of folate on cancer progression in pts with colorectal cancer
A prospective, nested observational study within 2 large US cohorts
Folate levels were measured among 301 participants who developed colorectal cancer 2 or more years after their plasma was collected
Results
Higher levels of plasma folate were not associated with an increased risk of colorectal cancer–specific or overall mortality
Those in the highest quintile experienced a multivariable-adjusted hazard ratio for colorectal cancer–specific mortality of 0.42
No detrimental effect of high plasma folate was noted in participants whose plasma was collected within 5 yrs of cancer diagnosis
No subgroup demonstrated worse survival among participants with higher plasma folate levels
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