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Prognostic significance of Nottingham histologic grade in invasive breast carcinoma
Journal of Clinical Oncology, 07/03/08

Rakha EA et al. - In a study to assess the prognostic significance of Nottingham histologic grade in invasive breast carcinoma, it was shown that histologic grade is strongly associated with both breast cancer–specific survival (BCSS) and disease-free survival (DFS) in the whole series as well as in different subgroups based on tumor size and LN stages

• This study is based on 2219 cases of operable breast cancer treated according to standard protocols in a single institution
• Follow-up was 111 months
• The goal was to assess the prognostic value of routine assessment of histologic grade using Nottingham histologic grading system

• Histologic grade is strongly associated with both BCSS and DFS in the whole series as well as in different subgroups based on tumor size (pT1a, pT1b, pT1c, and pT2) and LN stages (pN0 and pN1 and pN2)
• Differences in survival were also noted between different individual grades (1, 2, and 3)
• Histologic grade is an independent predictor of both BCSS and DFS in operable breast cancer as a whole as well as in all studied subgroups

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