Zhao-yang Z et al. - In a study to investigate apoptosis and its related signal pathways to integrin αvβ6 in colon cancer cells, it was shown that integrin αvβ6 played an important role in inhibiting apoptosis in colon cancer cells, and the signaling involved the mitochondrial pathway Methods
The function of integrin αvβ6 was blocked in HT29 cells used the monoclonal antibody
Results
After blocking the function of integrin αvβ6 in HT29 cells used the monoclonal antibody, apoptotic cells increased markedly
Cytochrome C released from mitochondria into cytosol, Bcl-2 decreased while Bax increased significantly, and Fas and Fas-ligand had no change
Activities of caspase-3 and caspase-9 increased, while caspase-8 remained unchanged
Expression of phosphorylated extracellular signal-related kinase decreased
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