Singh H et al. - In a trial to investigate the association of MMP-7 − 181A > G gene polymorphism with risk of cervical cancer, it was shown that individuals with MMP-7 − 181GG genotype were at significantly higher risk of cervical cancer Methods
150 cervical cancer pts were enrolled and confirmed by histopathology and 162 unrelated healthy individuals were enrolled
Polymorphism for MMP-7 gene (− 181A > G) was genotyped by polymerase chain reaction and restriction enzyme length polymorphism
Results
Frequency of MMP-7 − 181GG genotype and − 181G allele differed significantly between pts with cervical cancer and healthy individuals
Individuals with MMP-7 − 181GG genotype were at higher risk of stage II cervical cancer with borderline significance
Interaction of MMP-7 − 181AG and GG genotypes with tobacco usage did not modulate the cervical cancer risk significantly
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