Durbecq V et al. - In a trial to investigate the influence of ageing on the incidence of breast cancer (BC) molecular subtypes, it was shown that age has a great influence on the incidence of BC molecular subtypes Methods
According to their bio-characteristics, 61% of the samples could be assigned to a molecular subtype: the “HER-2+”, the “ER & HER2 negative”, or 1 of the 2 “luminal-like” subtypes divided according to their histological grade (“A” [HER-2-/ER+/grade 1–2] and “B” [HER-2-/ER+/grade 3])
Results
Pts <40 develop a statistically higher rate of high grade proliferating “HER-2” (27%) and “ER & HER2 negative” (31%) BC, whereas pts >50 develop mostly less aggressive hormone-dependant “luminal-A” BC (>67%)
A significant proportion of pts >70 develop “luminal-B” (19%) tumours associated with high proliferation, high grade, large size, and nodal invasion
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