Merseburger AS et al. – Activation of the PI3K pathway is significantly associated with adverse clinical outcome in renal cell carcinoma (RCC); analysis of biomarker combinations may identify high-risk pts and the need to modify treatment Methods
Study of expression patterns of Akt pathway parameters PI3K, phosphatase and tensin homolog (PTEN), phosphor-Akt (p-Akt) and their combination, for prognostic value in RCC
Immunohistochemical analysis of tumor samples from 176 RCC pts for PTEN, p-Akt and PI3K expression
Correlation of expression levels to clinical variables and postoperative outcome by uniivariate and multivariate analysis
Results
Expression levels were independent of histologic grade and tumor stage, due to different activation levels of the PI3K/p-Akt pathway
PI3K protein activation was significantly associated with reduced survival times
Decreased long-term survival correlated with PTEN low/p-Akt high expression
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