hemeonclinx Medical News about Hemoglobin E; Alpha-thalassemia; screening

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Hemoglobin E; Alpha-thalassemia; screening

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Effective screening for double heterozygosity of Hb E/alpha^0-thalassemia
Annals of Hematology, 06/27/08

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Free Abstract

Sanchaisuriya K et al. - E level < 26%, MCV < 74 fl, and MCH < 24 pg could be used for screening alpha^o-thalassemia in heterozygous Hb E. However, to improve specificity and PPV of the tests, a combination of Hb E level < 26% with either MCV < 74 fl or MCH < 24 pg is recommended.

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