hemeonclinx Medical News about sickle cell disease; hyperhemolysis syndrome

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Win N et al. - This is the second reported case of recurrent HS in a child. Recent studies have shown that the adhesion molecules expressed on RBC erythroid precursor cells and reticulocytes can interact with macrophages and can cause hemolysis. Because RBC alloantibodies and HLA antibodies were not identified in this case, it is believed that the patient's cells and transfused cells were destroyed by macrophages either by direct contact lysis or by erythrophagocytosis. The possible mechanism of IVIG and steroids on suppression of macrophages resulting in cessation of hemolysis is discussed.

--- ANEMIA/POLYCYTHEMIA TOP ARTICLES ---

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Quality-of-Life Assessment for Routine Oncology Clinical Practice
The Journal of Supportive Oncology, 06/16/08

Severe hemorrhage in children with newly diagnosed immune thrombocytopenic purpura
Blood, 08/27/08

Pilot study of continuous co-infusion of morphine and naloxone in children with sickle cell pain crisis
American Journal of Hematology, 06/13/08

...All of Anemia/Polycythemia

--- COAGULATION/BLEEDING DZ TOP ARTICLES ---

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Quality-of-Life Assessment for Routine Oncology Clinical Practice
The Journal of Supportive Oncology, 06/16/08

Pediatric antiphospholipid antibodies and antiphospholipid syndrome
Seminars in Thrombosis and Hemostasis, 08/22/08

Neurologic symptoms as a feature of the antiphospholipid syndrome
Seminars in Thrombosis and Hemostasis, 08/22/08

...All of Coagulation/Bleeding Dz

--- PEDIATRIC HEME/ONCOLOGY TOP ARTICLES ---

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Quality-of-Life Assessment for Routine Oncology Clinical Practice
The Journal of Supportive Oncology, 06/16/08

Pediatric antiphospholipid antibodies and antiphospholipid syndrome
Seminars in Thrombosis and Hemostasis, 08/22/08

Renal late effects in patients treated for cancer in childhood: A report from the Children's Oncology Group
Pediatric Blood & Cancer, 08/11/08

...All of Pediatric Heme/Oncology

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Efficacy of red blood cell transfusion in the critically ill
Critical Care Medicine, 09/04/08

Cost-effectiveness of rituximab in refractory cold agglutinin disease
International Journal of Laboratory Hematology, 08/14/08

Platelet transfusion refractoriness
British Journal of Haematology, 07/21/08

...All of Transfusion Medicine