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Overexpression of Pokemon in non-small cell lung cancer and foreshowing tumor biological behavior as well as clinical results
Lung Cancer, 07/03/08

Zhao ZH et al. - In a study to investigate the expression of Pokemon in non-small cell lung cancer (NSCLC) and to explore its correlation with the clinical pathological characteristics and its influence on pts’ prognosis, there was high expression of Pokemon in NSCLC; Pokemon exerted carcinogenesis by inhibiting alternative reading frame (ARF), and had some clinical significance for prognostic evaluation of NSCLC pts

Methods

Expression of Pokemon was determined in human NSCLC cell lines as well as 55 cases of NSCLC tumor tissues, tumor adjacent tissues, and surrounding tissues by reverse transcription-polymerase chain reaction (RT-PCR) and Western blot, and the relationship between Pokemon expression in NSCLC tumor tissues and clinicopathological features was analyzed
Immunohistochemical techniques were used to determine 62 NSCLC tumor tissues (5 years ago) and p14ARF expression
Correlation between them was observed and the effect of Pokemon on prognosis of pts with lung cancer was assessed

Results

Pokemon mRNA and protein took on high expression in lung cancer cell lines, and expression difference between cancer tissues, tumor adjacent tissues and surrounding tissues had statistical significance
Pokemon expression and p14ARF expression were negatively correlated; expression of Pokemon was determined not to be associated with the pt's sex, age, smoking condition, tumor differentiation degree, histology and lymph node metastasis condition
Its relationship with TNM staging was established
Survival rate of pts with negative Pokemon expression was significantly higher than that of those with positive Pokemon expression
Expression of Pokemon is believed to be an independent factor affecting prognosis