Jones TS et al. – CRHR1 polymorphisms may affect the risk of bone density deficits in a sex-specific manner in acute lymphoblastic leukemia (ALL) pts treated with corticosteroids and anti-metabolites Methods
Study of whether CRHR1 polymorphisms predict which ALL pts are likely to develop bone mineral deficits
Quantitative computed tomography of the trabecular lumbar spine to determine mean bone mineral density z scores of 309 long-term survivors of ALL
Analysis of whether CRHR1 genotypes, adjusted for sex, ALL treatment regimen, and weight, could predict bone density
Results
3 single nucleotide polymorphisms, all in linkage disequilibrium, were associated with bone density in a sex-specific manner
Bone density lower in males, nonblack pts, non-overweight pts, and in pts who received intensive antimetabolites and glucocorticoids
After adjustment for these features, the G allele at the rs1876828 SNP was associated with lower z scores in males but tended to the opposite association in females
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