Sathyana KM et al. – CCND1 polymorphisms can act as cis-acting regulatory elements modulating its expression; cyclin D1 genotype and phenotype may be a prognostic aid for oral cancer pts Methods
Study of the role of CCND1 A870G and C1722G polymorphisms on cyclin D1 expression and prognosis
Review of relatively homogenous population of 178 oral squamous cell carcinoma pts
PCR-SSCP, RFLP, RT-PCR and immunohistochemical analysis
Results
Genotype frequencies of both polymorphisms conformed to Hardy–Weinberg equilibrium
CCND1 A870G and C1722G polymorphisms were significantly associated with cyclin D1 expression
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