Overmeyer JH et al. - These observations provide evidence for a necrosis-like form of cell death initiated by dysregulation of macropinocytosis, which the authors have dubbed "methuosis." An activated form of the Rac1 GTPase induces a similar form of cell death, suggesting that Ras acts through Rac-dependent signaling pathways to hyperstimulate macropinocytosis in glioblastoma. Further study of these signaling pathways may lead to the identification of other chemical and physiologic triggers for this unusual form of cell death.
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