Ghadersohi A et al. – An inverse correlation is reported between prostate-derived Ets transcription factor (PDEF) and survivin expression, suggesting increased PDEF expression with reduced survivin is associated with prolonged survival in ovarian cancer pts Methods
Study of PDEF expression in tumors of ovarian cancer pts and its association with survival
Evaluation of samples from 40 ovarian cancer pts
Results
Higher levels of PDEF mRNA and protein and lower levels of survivin in early-stage (IA) and borderline (IIB, III) ovarian tumors vs late-stage ovarian tumors (IIIC and IV)
Highest levels of PDEF mRNA and protein in normal ovarian vs tumor tissues
Overall survival significantly longer for pts with PDEF-positive and survivin-negative ovarian tumors vs PDEF-negative and survivin-positive tumors
Forced PDEF expression in PDEF-negative ovarian tumor cells inhibited tumor cell growth, induced apoptosis, and downregulated survivin expression and its promoter activity
Treatment of ovarian cancer cells with vitamin D or a selenium compound resulted in PDEF re-expression, survivin downregulation, apoptosis induction, and tumor cell growth inhibition, vs untreated controls
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