Mark T et al. – Cyclophosphamide (Cy) can be added to granulocyte-colony stimulating factor (G-CSF) for stem cell mobilization to successfully overcome the suppressive effect of prior treatment with lenalidomide in multiple myeloma (MM) Methods
Study combination clarithromycin, lenalidomide, and dexamethasone (BiRD) in 28 treatment-naïve stage II or III MM pts
Stem cells collection after G-CSF or Cy plus G-CSF mobilization at maximum response
Results
Stem cell collection sufficient for 2 autologous stem cell transplants from all patients mobilized with Cy plus G-CSF vs 33% mobilized with G-CSF alone
Duration of prior lenalidomide therapy did not correlate with success of stem cell harvests
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