Agorastos T et al. - Data presented in this study suggest that human papillomavirus (HPV)-infected individuals are less likely to develop cervical neoplasia if adeno-associated virus (AAV) is present; AAV probably demonstrates a protective role against the pathogenic consequences of HPV infection. Methods
Study to investigate whether AAV infection reduces the risk for HPV-related cervical neoplasia
A prospective descriptive analysis of the prevalence of AAV and HPV DNA sequences in women with and w/o neoplastic cervical lesions
Study population: 373 women (age=19-65 y)
Cytologic and colposcopic examination, AAV and HPV-DNA detection and typing were performed
Biopsies and treatment were performed as appropriate
Women with normal Papanicolaou smear test and colposcopic findings served as the control group (n=280)
Results
Women with proven cervical pathology were categorized into three groups:
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