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Mutations in Both KRAS and BRAF May Contribute to the Methylator Phenotype in Colon Cancer
Gastroenterology, 06/25/08

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Free Abstract

Nagasaka T et al. - CIMP in CRC may result from activating mutations in either BRAF or KRAS, and the inclusion of additional methylation markers that correlate with mutant KRAS may help clarify CIMP in future studies. Additionally, aberrant DNA methylation is a common event not only in sporadic CRC but also in Lynch syndrome CRCs.

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