Devon C. Hall et al. - These results indicate that maspin expression plays a role in reducing the tumor cell's ability to seed to bone or in inhibition of growth in the bone microenvironment, but not to metastasize to distant sites. Methods
Study to determine whether maspin is the tumor/metastasis suppressor for this phenotype
Genomic clone containing the maspin gene was transfected into PC-3 cells that aggressively metastasize to bone in an animal model
Results
The BAC transfected PC-3 cells exhibited an in vitro phenotype consistent with maspin acting as a tumor suppressor
Analysis of the PC-3 maspin transfectants resulted in reduction of the no. and severity of skeletal metastasis vs parental PC-3 cells
However, maspin had no effect on the ability of PC-3 cells to metastasize to extra-skeletal sites in this model
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