Pinho MB et al. - The data presented here identify XAF1 as a novel predictive and prognostic factor in bladder cancer patients. Methods
Aim was to investigate whether mRNA expression of the apoptosis-associated genes, XAF1 and XIAP, in bladder cancer patients correlates with response to neoadjuvant treatment
Gene expression was analyzed by qRT-PCR method in paired samples from 14 treated bladder cancer pts
The prognostic significance of XAF1 and XIAP mRNA expression and their correlation with clinical and pathological findings were evaluated
Results
The clinical response in the XAF1-high subset was remarkably higher vs XAF1-low subset
These results translated into a notably improvement of PFS in the XAF1-high subset
In addition, pts in the XAF1-high subset had a 3.9-fold decreased chance of dying from the disease
No associations with the clinical response, the length of PFS, and OS and XIAP expression
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