Mohty M et al. - The authors found that patients expressing BMI-1 at 'high' level before allo-SCT had an improved overall survival related to a reduced transplant-related mortality. In multivariate analysis, when adjusted for the EBMT-Gratwohl score and other prognostic factors, there was an independent association between BMI-1 expression and grade 2-4 acute graft-versus-host disease suggesting that BMI-1 measured prior to allo-SCT can serve as a biomarker for predicting outcome in CP-CML patients receiving allo-SCT, and may thus contribute to better therapeutic decisions.
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