Majed B et al. - In a study to explore whether use of different Body Size Indicators (BSI) and cut-points can be used to indicate prognosis in breast cancer, it was found that efficient, optimal BSI cut-points indicate a poorer prognosis Methods
14,709 women were recruited, treated and followed for a first unilateral breast cancer
After randomly splitting pts’ data into 2 groups, a maximum statistical outcome approach was used to select optimal BSI cut-points from a “training sample”
External validation was carried out using a “validation sample” and agreement between the selected optimal BSI cut-points was assessed
Body Mass Index (BMI), weight, Ideal Weight Ratio, and Body Surface Area were assessed at the time of diagnosis
Results
Selected optimal BSI cut-points were reliable when overall survival, metastasis recurrence, and disease free interval events were investigated
Chosen BMI cut-point values matched the overweight cut-point value
Agreement between defined binary BSI was acceptable; however, it varied from “fair” to “very good”
When local and node recurrence events were taken into account, results were inconsistent and were linked to an unconfirmed relationship between stoutness and these prognosis events
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