Chang HM et al. - In a trial to evaluate the prevalence of PDGFRα mutations and corresponding protein expression in gastrointestinal tumors (GISTs) to determine their usefulness in obtaining a prognosis, it was shown that PDGFRα mutations in GISTs were rare in this Korean population. Although localized GISTs with PDGFRα mutations showed relatively good prognosis after resection, the difference was not statistically significant Methods
Genomic DNA was extracted from paraffin-embedded tumor tissues from 194 GISTs
Exons 12, 14 and 18 of the PDGFRα were amplified and sequenced
Immunohistochemical staining was performed in 179 pts
Results
Mutations in PDGFRα were detected in 6 pts, and were observed solely in KIT wild-type GISTs
Among the 6 pts with PDGFRα gene mutations, 5 pts with localized GISTs showed no relapse after resection during the 19- to 80-month follow-up period
Intensity of PDGFRα expression was classified as 0 in 26, 1+ in 69, 2+ in 71, and 3+ in 13 pts
Levels of PDGFRα expression showed no correlation with relapse-free survival
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