Matsubaraa J et al. – Insulin-like growth factor type 1 receptor (IGF-1R) and epidermal growth factor receptor (EGFR) may predict survival in gastric cancer (GC); further study on the strategy of co-targeting is warranted Methods
Study of the clinical implications of IGF-1R, EGFR, and HER2 expressions in GC
Review of 86 advanced GC pts who had first-line chemotherapy
Laser microdissection and real-time RT-PCR assay for mRNA levels of IGF-1R, EGFR and HER2 in paraffin-embedded surgical specimens of primary tumors
Results
Univariate analysis: overall survival significantly longer in 13 pts with low expression of both IGF-1R and EGFR (median, 24.6 mo) vs 51 other pts (12.8 mo)
Multivariate survival analysis: high EGFR expression and poor performance status are significant predictors of poor survival
In 29 first-line S-1 monotherapy pts, low IGF-1R and low EGFR gene expression correlated with a better response, without a significant prolongation of survival
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