Xiao-Dong F et al. - In a study to investigate the effects of progesterone (P), medroxyprogesterone acetate (MPA), drospirenone (DRSP), and nestorone (NES) alone or with 17beta-estradiol (E2) on T47-D breast cancer cell migration and invasion, these results imply that P, MPA, DRSP, and NES alone or in combination with E2 enhance the ability of breast cancer cells to move in the surrounding environment. These findings support the concept that each progestin acts differently on breast cancer cells Methods
The effects of progesterone (P), medroxyprogesterone acetate (MPA), drospirenone (DRSP) and nestorone (NES) alone or with 17beta-estradiol (E2) were investigated on T47-D breast cancer cell migration and invasion
Some of these actions were linked to regulation of the actin-regulatory protein, moesin and to cytoskeletal remodeling
Results
Breast cancer cell horizontal migration and invasion of 3-dimensional matrices are enhanced by all the progestins, but differences are found in terms of potency, with MPA being the most effective and DRSP being the least
This is related to the differential ability of the progestins to activate the actin-binding protein moesin, leading to distinct effects on actin cytoskeleton remodeling and on formation of cell membrane structures that mediate cell movement
E2 also induces actin remodeling through moesin activation
The addition of some progestins partially offsets the action of estradiol on cell migration and invasion of breast cancer cells
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