Yu G et al. – Annexin A1 (ANXA1) expression decreased significantly with gastric cancer progression and metastasis and thus may serve as an important negative biomarker Methods
Study of ANXA1 expression and determined its clinical significance in gastric cancer
Immunohistochemical analysis of ANXA1 expression in tissue microarray blocks containing primary gastric cancer, lymph node metastasis, and adjacent normal mucosa from 1,072 Chinese pts
Results
Complete loss of ANXA1 expression in 691 (64%) of 1,072 primary tumors and in 146 (86%) of 169 nodal metastases
Expression loss significantly associated with advanced T stage, lymph node metastasis, advanced disease stage, and poor histologic differentiation
In both univariate and multivariate analyses, ANXA1 expression loss correlated significantly with poor survival rates
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