Beer AJ et al. - Molecular imaging of alphavbeta3 expression could potentially facilitate response evaluation of antiangiogenic drugs (e. g. bevacizumab) or aid in selecting and monitoring patients receiving humanized monoclonal antibody therapies directed against alphavbeta3 (EMD121974). While optical imaging techniques lend themselves for preclinical studies, PET and SPECT using the v3 specific tracers [18F]galacto-RGD and [99mTc]NC100692 are the only techniques up to now which have been successfully used in patients. The various advantages and disadvantages of several imaging techniques will be discussed in this article.
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