Brunello F et al. – CR rate 1y after percutaneous treatment of early HCC was significantly better with RFA than with PEI but did not provide a clear survival advantage in cirrhotic patients. Methods
Randomized trial with 139 cirrhotic pts in Child-Pugh classes A/B with 1-3 nodes of HCC (diameter 15-30 mm), for a total of 177 lesions
Pts were randomized to receive RFA (n=70) or PEI (n=69)
Results
1y CR was achieved in 46/70 (65.7%) and in 25/69 (36.2%) pts treated by RFA and PEI, respectively
For lesions >20 mm in diameter, there was a larger CR rate in the RFA group (68.1% vs 26.3%)
An early CR was obtained in 67/70 (95.7%) pts treated by RFA compared with 42/64 (65.6%) pts treated by PEI
Complications occurred in 10 and 12 pts treated by RFA and PEI, respectively
OS rate was not significantly different in the RFA vs PEI arm
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