hemeonclinx Medical News about Colorectal Cancer; tumorigenesis; Claudin-7

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Colorectal Cancer; tumorigenesis; Claudin-7

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Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells
Cancer Research, 06/09/08

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Free Abstract

Darido C et al. - Our results indicate that Tcf-4 maintains low levels of claudin-7 at the bottom of colonic crypts, acting via Sox-9. This negative regulation seems to be defective in CRC, possibly due to decreased Sox-9 activity, and the resulting claudin-7 overexpression promotes a loss of tumor cell polarization and contributes to tumorigenesis.

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