Ben-Josef E et al. - In a review of the use of chemoradiotherapy for unresectable pancreatic cancer, it seems that while it is clear that breakthroughs in treatment would come mostly from advances in systemic therapy, the evidence suggests that radiotherapy should not fall out of use, but rather be intensified Methods
Although quality data on the benefit of radiotherapy in unresectable pancreatic cancer are lacking, it seems unlikely that the low-efficacy chemotherapy used for pancreatic cancer would control gross disease
Current regimens deliver low, ineffective doses of radiation and are associated with high rates of local failure
Results
New technological advances, such as intensity-modulated radiotherapy, now allow the safe delivery of high-dose, highly conformal radiotherapy concurrently with full systemic doses of chemotherapy
This review discusses new knowledge related to pattern of failure, target definition, and target motion and discusses the implications of these data on modern radiotherapy treatment planning and delivery
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