Beiner ME et al. - In a trial to explore whether or not there is an association between the presence of either of the germline mutations in the MutY human homologue (MYH) gene (Y165C and G382D) and the risk of breast cancer, it was determined that carriers of the MYH Y165C or G382D mutant alleles do not appear to be at increased risk for breast cancer Methods
691 breast cancer pts and 812 healthy controls were genotyped for the MYH Y165C and G382D mutations
The frequencies of heterozygotes, homozygotes, and compound heterozygotes were compared for the 2 groups
Results
4 of 691 breast cancer cases carried a MYH Y165C mutant allele, compared to 5 of the controls
8 cases carried a MYH G382D mutant allele, compared to 8 of the controls
No case or control was homozygous for the variant and none were compound heterozygotes
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