Marioni G et al. – Nuclear mammary serine protease inhibitor (MASPIN) has an apoptosis-sensitizing effect in laryngeal carcinoma; the tumor-suppressive proapoptotic function may be of clinical use Methods
Study of relationship between subcellular expression of MASPIN, nuclear MASPIN expression, M30 expression, and prognosis in laryngeal carcinoma
Immunohistochemical analysis of subcellular pattern of distribution of MASPIN and nuclear MASPIN expression in 66 consecutive cases of laryngeal carcinoma
Calculation of M30 expression in correspondent carcinoma
Results
M30 expression significantly higher laryngeal carcinomas with MASPIN nuclear localization
Carcinoma recurrence rate reduced in patients with MASPIN nuclear localization
Disease-free interval significantly longer in pts with nuclear MASPIN localization as noted by log-rank test
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