Diensthuber M et al. – Expression of hypoxia-inducible factor (HIF)-1alpha, erythropoietin (Epo) expression, erythropoietin receptor (EpoR), and the anti-apoptotic protein bcl-2 may have a functional role in pathogenesis of olfactory neuroblastoma (ONB); bcl-2 may stimulate angiogenesis in ONB and may serve as a target for anti-angiogenic treatment in ONB Methods
Immunohistochemical analysis of 20 ONB samples for expression of HIF-1alpha, Epo, EpoR by Epo, and bcl-2
Data correlated with microvessel density, proliferative activity, and apoptosis
Survival analysis for prognostic value of the examined factors
Results
HIF-1alpha, Epo, EpoR, and bcl-2 highly expressed in ONB
HIF-1alpha immunoreactivity in 90% of samples; bcl-2 immunoreactivity in 60%
Significant positive correlation between HIF-1alpha and bcl-2 expression and microvessel density
Survival analysis showed no prognostic significance for tested factors
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