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Technology Advances: CISH technology Facilitates Assay of HER2 Expression
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D Scott Cunningham MD, PhD, MDLinx Oncology
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endometetroid adenocarcinoma;clinical stage I Article Summary

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The role of omentectomy during the surgical staging in patients with clinical stage I endometrioid adenocarcinoma
Journal of Cancer Research & Clinical Oncology, 05/19/08
Print     Email This Article     Save in My Library   Free Abstract
Metindir J et al. - In a study to evaluate whether omentectomy should be a routine part of staging surgery in endometrioid adenocarcinoma, it was shown that despite the presence of normal-appearing omentum, omentectomy should be performed as a component of surgical staging in the presence of positive peritoneal cytology

Methods
  • A retrospective study was performed on 65 pts who were primarily treated by total abdominal hysterectomy, salpingo-oophorectomy, bilateral pelvic and para-aortic lymphadenectomy, infracolic omentectomy and peritoneal cytology for clinical stage I endometrial carcinoma
  • Data on 65 pts diagnosed with clinical stage I endometrial carcinoma were reviewed
  • Associations in the data obtained, pelvic and para-aortic lymph node status, depth of myometrial invasion, grade, vascular invasion, adnexal involvement, positive peritoneal cytology, lymph node metastasis, cervical stromal invasion, and tumor size, were investigated

Results
  • 4 of 65 pts had omental metastasis, which was microscopic in 2 pts
  • As for extrauterine spread, the positivity rate of lymph node metastases was 10/65, peritoneal cytology was 7/65, and adnexal metastases was 10/65
  • Of those with omental metastasis, 2/10 had positive nodes, 2/10 had adnexal metastases, and 3/7 had positive peritoneal cytologic findings
  • The 4 pts with omental metastasis had significantly higher rates of positive cytology
  • Multivariate analysis revealed omental metastasis to be significantly associated with positive peritoneal cytology

 

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