Pan K et al. - In a study to investigate indoleamine 2,3-dioxygenase (IDO) expression in hepatocellular carcinoma (HCC) cell lines and primary HCC clinical surgical specimens, it was shown that IDO may be a novel favorable prognostic indicator and candidate adjuvant therapeutic target for HCC Methods
IDO expression was investigated in HCC cell lines and 138 primary HCC clinical surgical specimens
IDO expression was correlated with clinical outcomes and prognosis of HCC pts
Results
Reverse transcription-PCR analysis showed that in vitro IDO expression in HCC cell lines and non-cancerous liver cell line were dependent on IFN-γ
Immunohistochemical detection revealed that IDO was overexpressed in 49 of 138 tumor resection samples, whereas 89 of 138 cases showed weak immunostaining
IDO overexpression was significantly correlated with high metastasis rates
Kaplan–Meier survival curves showed that overexpression of IDO resulted in significantly poor prognosis
Multivariate Cox’s analysis showed that IDO expression was an independent prognostic factor for overall survival of HCC pts
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