Tao W et al. - in a study to evaluate the association between HER2 codon 655 polymorphism and breast cancer risk, it was shown that HER2 codon 655 Val allele is weakly associated with an increased risk of breast cancer, and SNP at HER2 codon 655 could be considered a susceptibility biomarker for breast cancer for Asian females or women age 45 years or younger Methods
A search was performed to identify all case–control studies investigating such association
Statistical analyses were conducted with software MIX 1.54
20 eligible reports, including 10,642 cases/11,259 controls, were identified
Results
Overall, the Val allele frequency in cases was significantly higher than that in controls, while no associations were found in both recessive and dominant models
In subgroup analysis, HER2 codon 655 polymorphism was weakly associated with breast cancer risk in recessive, dominant, and co-dominant genetic models in Asian population, respectively
The susceptibility to breast cancer in people aged <=45 was significantly increased in both recessive and dominant models
No significant associations were observed in Caucasian, European, and family history subgroups
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