Kubo H et al. - Direct and indirect inhibitory effects of human interferon-β (HuIFN-β) on human melanoma cells are demonstrated that suggest a need for local higher concentration of HuIFN-β to eradicate melanoma lesions. Methods
Aim was to investigate the anti-tumor effect of HuIFN-β against malignant melanoma
In vitro studies were carried out in melanoma cell lines: MM-AN, MM-BP, MM-LH, MM-RU, PM-WK, RPM-EP, RPM-MC
For in vivo studies, HuIFN-&beta was administered into cutaneous metastatic lesions of melanoma to evaluate the clinical and histopathological effects
Results
In vitro study revealed that HuIFN-&beta not only inhibited proliferation of melanoma cells but also induced apoptosis in a dose dependent fashion
The sensitivity to HuIFN-β was different among cell lines
Size of the metastatic cutaneous lesion did not change by the intralesional injection of HuIFN-β
However, histopathological examination revealed apoptotic changes of melanoma cells along with dense lymphohistiocytic infiltration
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