Seki N et al. - In a study to clarify the features of localized ground-glass attenuation (GGA) cancer as a distinct clinicoradiological entity through a survey of lung cancers of all types, it was shown that localized GGA cancer, with presurgical prognostic factors of tumor size and GGA ratio, represents early-stage lung adenocarcinoma in nonsmokers Methods
492 pts with newly diagnosed stage I-IV lung cancer underwent thin-section computed tomography (TSCT)
Tumors were semiquantitatively classified into 4 groups on the basis of GGA area as a percentage of the whole tumor shadow (GGA ratio) on TSCT images: 100%, 99-50%, 49-1%, and 0%
The relationship between clinicopathological data and the GGA ratio, predictors of the presence of GGA, survival data, and prognostic factors were evaluated retrospectively
Results
All localized GGA cancers were adenocarcinomas
A GGA component was not found in pts with advanced cancer
GGA cancer was related to nonsmoking status
A threshold tumor size of 30 mm in GGA cancer and the GGA ratio were independent prognostic factors
Survival rates were higher in pts with a GGA ratio >=50% and stage IB lung cancer than in pts with a GGA ratio <50% and stage IA lung cancer
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