Katsabeki-Katsafli A et al. - In a study to determine the serum VEGF levels and oxidative stress in pts with primary lung cancer and to investigate their association with clinicopathologic factors, it was shown that oxidative stress and VEGF are significantly increased in pts with primary lung cancer Methods
Serum VEGF levels and oxidative stress were measured in 63 pts with primary lung cancer before any treatment and 25 normal subjects
Serum VEGF levels were measured with enzyme linked immunosorbent assay
Serum oxidative stress levels were detected by a commercially available assay
Results
Levels of oxidative stress in pts were higher than those in normal subjects
A significant difference was found in serum VEGF levels between lung cancer pts and healthy controls
Serum oxidative stress presented a significant correlation with serum VEGF levels in pts with lung cancer
Serum VEGF levels were significantly associated with the clinical staging of the pts, performance status, and age
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