Shi H-Z et al. – In a study to determine the accuracy of carcinoembryonic antigen (CEA) measurement in the diagnosis of MPE, it was found that measurement of pleural CEA may be a useful diagnostic tool for confirming MPE, and is also helpful in the differential diagnosis between malignant pleural mesothelioma and metastatic lung cancer Methods
Meta-analysis of the accuracy of CEA measurement in diagnosis of MPE
Random effects model to pool data on accuracy of pleural CEA concentrations in MPE diagnosis
ROC curves to summarize the overall test performance
Results
Inclusion criteria met by 45 studies
Summary estimates for CEA in MPE diagnosis: sensitivity 0.54, specificity, positive likelihood ratio 9.52, negative likelihood ratio 0.49, and diagnostic odds ratio 22.5
On subset analysis of a pleural CEA value to rule out malignant mesothelioma diagnosis (11 studies), sensitivity and specificity of a CEA level exceeding cut-off values were 0.97 and 0.60, respectively
See all
