Taylor ML et al. - In a trial to determine an association between statins and breast cancer, colon cancer, lung cancer, prostate cancer, or any cancer in case-control studies, it was found that a significant association between statin usage and any cancer exists, but when stratified by cancer type, only the association with colon cancer remained Methods
A comprehensive search for studies published through November 2006 was performed
20 case-control studies of 100,129 incident cancer cases were combined to obtain a pooled odds ratio using an inverse variance method
Results
A funnel plot did not suggest a significant absence of unpublished data
Studies were significantly heterogeneous, thus a random effects model was used
The pooled OR and 95% confidence intervals for statin users and cancer were as follows: any cancer 0.71, breast cancer 0.86, colon cancer 0.89, lung cancer 0.75, and prostate cancer 0.74
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