van Soest EM et al. - In a study to investigate the association between the use of proton pump inhibitors (PPI) and the risk of colorectal cancer (CRC), it seems that no association was found between PPI use and the risk of CRC Methods
Cases with CRC were matched with up to 20 controls on age, gender, calendar time, and duration of follow-up prior to diagnosis
Cumulative exposure to PPIs was assessed in the 5 yr prior to diagnosis with a 1-yr lag time analysis
Adjusted odds ratios (OR) were calculated with 95% confidence intervals using multivariate, conditional logistic regression analysis
Results
Within the source population of 457,024 persons, 595 CRC cases were identified
The odds of CRC were not increased among pts ever using PPIs compared with pts who never used PPIs
Use of PPIs for >365 days was not associated with a greater risk of CRC compared with nonusers
The odds of CRC in neither the right nor the left hemicolon were significantly increased in pts using PPIs
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