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See Latest ArticlesGene expression signatures, clinicopathological features, and individualized therapy in breast cancer
JAMA, 04/03/08
Acharya CR et al. - Incorporation of gene expression signatures into clinical risk stratification can refine prognosis
Methods- Retrospective study of early stage breast carcinoma candidates for adjuvant chemotherapy
- Review of microarray data for 964 clinically annotated breast tumor samples (573 in initial set; 391 in validation cohort)
- Relapse risk scores based on respective clinicopathologic features
- Main outcome measures: gene expression signatures and clinicopathological variables in early stage breast cancer to determine a refined estimation of relapse-free survival and sensitivity to chemotherapy
- In initial 573 pts, prognostically significant clusters as patterns of oncogenic pathway activation and tumor biology/microenvironment states were identified within the low-, intermediate-, and high-risk model cohorts
- Multivariate analyses confirmed independent prognostic value of genomic clusters
- Related, not identical, clusters in the independent validation cohort established reproducibility and validity of pathway deregulation patterns in predicting relapse risk
- The prognostic clinicogenomic clusters showed unique sensitivity patterns to commonly used cytotoxic therapies
Today in Basic Science/Genetics...keeping you current
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Potential predictive markers of chemotherapy resistance in stage III ovarian serous carcinomas
BMC Cancer, 10/21/09
Breast cancer in the elderly: a histological assessment
Histopathology, 10/15/09
Serum calcium levels are elevated among women with untreated postmenopausal breast cancer
Cancer Causes and Control, 11/03/09
Today in Breast...keeping you current
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Local excision alone without irradiation for ductal carcinoma in situ of the breast: A trial of the Eastern Cooperative Oncology Group
Journal of Clinical Oncology, 10/19/09
Docetaxel versus docetaxel alternating with gemcitabine as treatments of advanced breast cancer: final analysis of a randomised trial
Annals of Oncology, 10/13/09
Pomegranate fruit extract impairs invasion and motility in human breast cancer
Integrative Cancer Therapies , 10/12/09
Today in Pharmacology/Therapy...keeping you current
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Nonsteroidal anti-inflammatory drugs
Cancer, 10/16/09
Docetaxel versus docetaxel alternating with gemcitabine as treatments of advanced breast cancer: final analysis of a randomised trial
Annals of Oncology, 10/13/09
Lymphoma in patients treated with anti-TNF. Results of the 3-year prospective French RATIO registry.
Annals of Rheumatic Diseases, 10/22/09
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