Grainger EM et al. - Prostate cancer patients put on diet rich in tomato products and soy showed excellent compliance and bioavailability of phytochemicals. Further studies combining tomato and soy foods to determine efficacy for prostate cancer prevention or management are encouraged. Methods
Tomato and soy products are hypothesized to reduce the risk of prostate cancer or enhance efficacy of therapy
This study was undertaken to determine if active prostate cancer pts will adhere to this dietary intervention
Pts (n=41) with recurrent, asymptomatic prostate cancer were randomized among 2 groups:
Group A (n=20) consumed tomato products (no soy) for wks 0-4
Group B (n=21) consumed soy (no tomatoes) for wks 0-4
Results
For wks 4-8, all men consumed a combined tomato-rich diet and soy supplements
No grade II through IV toxicities were observed
During wks 0-4, mean daily lycopene intake for Group A was 43 mg and mean soy intake for Group B was 39 g
Serum lycopene increased from 0.72 b.mu mol/l to 1.21 b.mu mol/l and urinary isoflavone excretion increased from not detectable to 54.1 b.mu mol/l
Serum PSA decreased between wks 0 and 8 for 34% of men
Mean serum VEGF for the entire group was reduced from 87 to 51 ng/ml over 8 wks
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