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Activation and inhibition of the erythropoietin receptor by a membrane-anchored erythropoietin
Experimental Hematology, 03/19/08

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Free Abstract

Negre O et al. - Activation of EpoR gene expression before MbEpo-induced EpoR activation is essential for activation or inhibition of growth and differentiation of Epo-dependent cell lines. It will be necessary to delay MbEpo expression in late erythroid progenitors until after EpoR gene activation, for erythroid cell expansion to be achieved in vivo.

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