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Recommendations on the use of 18F-FDG PET in oncology
The Journal of Nuclear Medicine, 03/12/08

Fletcher JW et al. - In a trial to develop recommendations on use of 18F-FDG PET in breast, colorectal, esophageal, head and neck, lung, pancreatic, and thyroid cancer; lymphoma, melanoma, and sarcoma; and unknown primary tumor, it was recommended that 18F-FDG PET should be used as an imaging tool in addition to conventional radiologic methods such as CT or MRI

• A search was performed to identify all published randomized controlled trials and systematic reviews in the literature
• An additional search was performed to identify relevant unpublished systematic reviews
• Publications comprised both retrospective and prospective studies of varied methodologic quality
• Anticipated consequences of false-positive and false-negative tests when evaluating clinical usefulness, and impact of 18F-FDG PET on management of cancer pts, were also reviewed

• 18F-FDG PET should be used as an imaging tool in addition to conventional radiologic methods such as CT or MRI
• Any positive finding that could lead to a clinically significant change in pt management should be confirmed by subsequent histopathologic examination because of the risk of false-positive results
• 18F-FDG PET should be used in the appropriate clinical setting for the diagnosis of head and neck, lung, or pancreatic cancer and for unknown primary tumor

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