Johansson M et al. - In a trial to investigate the relationship between prostate cancer risk and circulating concentrations of folate and vitamin B12, it seems that results do not provide strong support for an association between prostate cancer risk and circulating concentrations of folate or vitamin B12 Methods
Circulating concentrations of folate and vitamin B12 were analyzed in 869 cases and 1174 controls, individually matched on center, age, and date of recruitment
Relative risks (RR) for prostate cancer were estimated using conditional logistic regression models
Results
No significant associations were observed for circulating concentrations of folate or vitamin B12 with prostate cancer risk
RRs for a doubling in folate and vitamin B12 concentrations were 1.03 and 1.12, respectively
In the subgroup of cases diagnosed with advanced stage prostate cancer, elevated concentrations of vitamin B12 were associated with increased risk
No other subgroup analyses resulted in a statistically significant association
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