Oncology Medical News

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Recommendations on the use of 18F-FDG PET in oncology

3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials

4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ
Annals of Surgical Oncology, 02/05/08

Dominguez FJ et al. - In a trial to determine the utility of sentinel node biopsy (SNB) for ductal carcinoma in situ (DCIS) and its potential to avoid axillary lymph node dissection (ALND) in patients undergoing mastectomy for DCIS, it was found that 11% of patients undergoing mastectomy for DCIS had invasive cancer on final pathology; use of SNB during mastectomy for DCIS allowed nearly all such patients to avoid axillary dissection

Methods

A review was conducted of 179 patients who underwent mastectomy with sentinel node biopsy for DCIS without invasion or microinvasion on premastectomy pathology review

Results

Sentinel node identification rate was 98.9%
11.3% of mastectomies for DCIS had a positive SNB: 2 micrometastasis (pN1mi) and 18 isolated tumor cells [pN0(i+)]
Unsuspected invasive cancer was found in 11.2% of the mastectomies, 8 T1mic, 5 T1a, 3 T1b, and 4 T1c tumors
Sentinel nodes were identified in 19 of 20 patients with invasive cancer and 4 were positive: 1 pN1mi and 3 pN0(i+)
18 of 19 patients with unsuspected invasive cancer were able to avoid axillary dissection on the basis of SNB results
Of the 159 patients whose final pathology revealed DCIS without invasion, a sentinel node was identified in 99.4%
SNB was positive in 16 patients: 1 pN1mi and 15 pN0(i+)
3 patients underwent ALND on the basis of positive SNBs and in each the SNB was the only positive node

<< Previous
A significant correlation between nuclear CXCR4 expression and...

Next >>
Development of new cancers in patients with DCIS: the M.D....