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Development of new cancers in patients with DCIS: the M.D. Anderson experience
Annals of Surgical Oncology, 02/05/08

Dawood S et al. - In a study to describe clinical characteristics and outcome of mammographically and clinically detected new cancers in patients with previously diagnosed ductal carcinoma in situ (DCIS), it was shown that second events following DCIS occur primarily in the opposite breast and have a negative impact on survival

Methods

A database was searched to identify patients with a primary diagnosis of DCIS
Patients with prior evidence of invasive carcinoma were excluded from the analysis
Cumulative incidence of new cancers was estimated according to the method of Gray

Results

799 patients diagnosed and treated for DCIS were included in the analysis
Median age at diagnosis was 54 years and median tumor size was 1.4 cm
After a median follow-up of 2.9 years, 45 patients had a second event: 14 with in-situ and 31 with invasive disease
Median disease-free interval was 3.5 years
The majority of second events occurred in the opposite breast and the cumulative incidence at 5 years was 6.6%
Overall survival at 5 years was 97.4%; that for the second event was 76.1%
For mammography and self-palpation, respectively, the 5-year survival by method of detection of the second event was 63.2% and 100%

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